Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours
Abstract
Phosphorylated Akt (P-Akt) is an attractive molecular target because it contributes to the development of breast cancer and confers resistance to conventional therapies. Akt also serves as a signalling intermediate for receptors such as human epidermal growth factor receptor (HER)-2, which is overexpressed in 30% of breast cancers; therefore, inhibitors to this pathway are being sought. New celecoxib analogues reportedly inhibit P-Akt in...
Paper Details
Title
Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours
Published Date
Aug 1, 2005
Journal
Volume
7
Issue
5
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