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Performance of a motor task learned on levodopa deteriorates when subsequently practiced off.

Published on Jan 1, 2014in Movement Disorders8.222
· DOI :10.1002/mds.25702
Elise D. Anderson2
Estimated H-index: 2
(OHSU: Oregon Health & Science University),
Fay B. Horak82
Estimated H-index: 82
(OHSU: Oregon Health & Science University)
+ 1 AuthorsJohn G. Nutt80
Estimated H-index: 80
(OHSU: Oregon Health & Science University)
Abstract
Studies in animals and in people with Parkinson's disease (PD) demonstrate complex effects of dopamine on learning motor tasks; its effect on retention of motor learning has received little atten- tion. Recent animal studies demonstrate that practicing a task in the off state, when initially learned in the on state, leads to progressive deterioration in performance. We measured the acquisition and retention of 3 different motor tasks in the presence and absence of levodopa. Twenty individuals with Hoehn and Yahr Stage 1.5 to 3 PD practiced the tasks daily for two 4-day weeks, one half practicing on L-dopa the first week and off the sec- ond week. The other half practiced off L-dopa both weeks. The tasks were (1) alternate tapping of 2 keys, (2) moving the body toward 2 targets on a posturogra- phy device, and (3) mirror drawing of a star. For the tap- ping and body movement tests, those who practiced on the first week had a progressive decline in perform- ance with practice during week 2, while subjects off during week 1 maintained or improved. In contrast, for the mirror task, subjects on L-dopa initially had much more difficulty completing the task compared to sub- jects who practiced off. Both groups improved with practice the first week and had flat performance the second week. These data suggest that performance of speed-accuracy tasks learned in the on state may pro- gressively worsen if subsequently practiced in the off state. In addition, performance, but not learning, of some tasks may be impeded by L-dopa. V C 2013 Inter- national Parkinson and Movement Disorder Society.
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References35
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The role dopamine plays in decision-making has important theoretical, empirical and clinical implications. Here, we examined its precise contribution by exploiting the lesion deficit model afforded by Parkinson’s disease. We studied patients in a two-stage reinforcement learning task, while they were ON and OFF dopamine replacement medication. Contrary to expectation, we found that dopaminergic drug state (ON or OFF) did not impact learning. Instead, the critical factor was drug state during the...
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Abstract We previously reported a differential effect of dopaminergic medication across the time course of motor sequence learning in early stage Parkinson's (PD) patients [1] . There was a medication-associated impairment specific to the early phase of learning. In the current study, we investigated the BOLD responses associated with this deleterious medication effect on motor sequence learning. We hypothesized that levodopa ( l -DOPA) would negatively affect the recruitment of the ventral stri...
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