Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin

Published on Sep 1, 2000in American Journal of Physiology-endocrinology and Metabolism4.13
· DOI :10.1152/ajpendo.2000.279.3.E630
Steven D. Mittelman30
Estimated H-index: 30
(SC: University of Southern California),
Richard N. Bergman96
Estimated H-index: 96
(SC: University of Southern California)
We have shown that insulin controls endogenous glucose production (EGP) indirectly, via suppression of adipocyte lipolysis. Free fatty acids (FFA) and EGP are suppressed proportionately, and when the decline in FFA is prevented during insulin infusion, suppression of EGP is also prevented. The present study tested the hypothesis that suppression of lipolysis under conditions of constant insulin would yield a suppression of EGP. N 6-cyclohexyladenosine (CHA) was used to selectively suppress adipocyte lipolysis during euglycemic clamps in conscious male dogs. FFA suppression by CHA caused suppression of EGP. Liposyn control experiments, which maintained FFA levels above basal during CHA infusion, completely prevented the decline in EGP, whereas glycerol control experiments, which maintained glycerol levels close to basal, did not prevent a decline in EGP. These controls suggest that the EGP suppression was secondary to the suppression of FFA levels specifically. A difference in the sensitivity of FFA and EG...
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