CCAAT/enhancer-binding protein α is required for hepatic outgrowth via the p53 pathway in zebrafish

Volume: 5, Issue: 1
Published: Oct 29, 2015
Abstract
CCAAT/enhancer-binding protein α (C/ebpα) is a transcription factor that plays important roles in the regulation of hepatogenesis, adipogenesis and hematopoiesis. Disruption of the C/EBPα gene in mice leads to disturbed liver architecture and neonatal death due to hypoglycemia. However, the precise stages of liver development affected by C/ebpα loss are poorly studied. Using the zebrafish embryo as a model organism, we show that inactivation of...
Paper Details
Title
CCAAT/enhancer-binding protein α is required for hepatic outgrowth via the p53 pathway in zebrafish
Published Date
Oct 29, 2015
Volume
5
Issue
1
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