ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosis

Wound healing consists of multiple consecutive, overlapping phases of inflammation, proliferation and remodelling. Acute wounds initiate an early inflammatory response, implicated in altering the subsequent phases of healing (1,S1). However, the effects of inflammation on wound closure rate and regeneration quality remain obscure. PU1 KO mice (deficient in myeloid lineage) and neutrophil-depleted mice have improved wound healing (2,S2), while...