The IgH locus 3' regulatory region: pulling the strings from behind.

Volume: 110, Pages: 27 - 70
Published: Jan 1, 2011
Abstract
Antigen receptor gene loci are among the most complex in mammals. The IgH locus, encoding the immunoglobulin heavy chain (IgH) in B-lineage cells, undergoes major transcription-dependent DNA remodeling events, namely V(D)J recombination, Ig class-switch recombination (CSR), and somatic hypermutation (SHM). Various cis-regulatory elements (encompassing promoters, enhancers, and chromatin insulators) recruit multiple nuclear factors in order to...
Paper Details
Title
The IgH locus 3' regulatory region: pulling the strings from behind.
Published Date
Jan 1, 2011
Volume
110
Pages
27 - 70
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