A novel aptasensor based on single-molecule force spectroscopy for highly sensitive detection of mercury ions
Abstract
We have developed a novel aptasensor based on single-molecule force spectroscopy (SMFS) capable of detecting mercury ions (Hg(2+)) with sub-nM sensitivity. The single-strand (ss) DNA aptamer used in this work is rich in thymine (T) and readily forms T-Hg(2+)-T complexes in the presence of Hg(2+). The aptamer was conjugated to an atomic force microscope (AFM) probe, and the adhesion force between the probe and a flat graphite surface was measured...
Paper Details
Title
A novel aptasensor based on single-molecule force spectroscopy for highly sensitive detection of mercury ions
Published Date
Jan 1, 2015
Journal
Volume
140
Issue
15
Pages
5243 - 5250
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