Control of Breast Cancer Using Organotin Polymers

Published on Nov 22, 2015in International Journal of Polymeric Materials 2.13
· DOI :10.1080/00914037.2015.1030650
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 7 AuthorsZamil Islam1
Estimated H-index: 1
(Florida Atlantic University)
Abstract
The efforts described in this article are aimed at designing organotin polymers that control the growth of breast cancer and to identify structure/property relationships that assist in this goal. The growth of MCF-7 and MDA-MB-231 breast cancer cell lines is inhibited employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. A number of products exhibit CI50 values greater than two including a number of organotin polyethers such as those derived from diethylstilbestrol, dienestrol, short-chained dibutyltin polyethers, and hydroquinone derivatives. In most of these cases the MDA-MB-231 cells exhibit greater inhibition compared to the estrogen receptor (ER) MCF-7 cells. The organotin polymers generally exhibit a superior ability to inhibit MCF-7 and MDA-MB-231 breast cell growth compared to the standard cisplatin.
  • References (37)
  • Citations (4)
Cite
References37
Published on Feb 18, 1972in Macromolecular Chemistry and Physics 2.49
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Gary A. Scherubel3
Estimated H-index: 3
(University of South Dakota)
Poly[alkylene(arylene)oxystannanes] of the form below have been synthesized from dichlorostannanes and diols using a modified nonaqueous interfacial system consisting of acetonitrile and hydrocarbons. The products are preferentially capped with alcohol end-groups. Poly[alkylen(arylen)oxystannane] der folgenden Struktur wurden durch Grenzflachenpolykondensation von Dichlorstannen mit Diolen hergestellt. Dabei wurden modifizierte wasserfreie Losungsmittelsysteme aus Acetonitril und Kohlenwassersto...
25 Citations Source Cite
Published on Sep 5, 2003
Alaa S. Abd-El-Aziz22
Estimated H-index: 22
,
Charles E. Carraher23
Estimated H-index: 23
+ 2 AuthorsMartel Zeldin6
Estimated H-index: 6
128 Citations Source Cite
Published on Oct 18, 1972in Macromolecular Chemistry and Physics 2.49
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Gary A. Scherubel3
Estimated H-index: 3
(University of South Dakota)
The synthesis of some poly(tin ethers) according to the following route is described The number average polymerization degrees range from 78 to 1400. Die Synthese einiger Poly-(zinnather) wird beschrieben, und zwar durch die in der Summary wiedergegebene Reaktion. Die mittleren Polymerisationsgrade liegen im Bereich von 78 bis 1400.
27 Citations Source Cite
Published on Jul 1, 2011in CA: A Cancer Journal for Clinicians 244.59
Rebecca L. Siegel43
Estimated H-index: 43
(American Cancer Society),
Elizabeth Ward74
Estimated H-index: 74
(American Cancer Society)
+ 1 AuthorsAhmedin Jemal96
Estimated H-index: 96
(American Cancer Society)
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. A total of 1,596,670 new cancer cases an...
3,124 Citations Source Cite
Elvire Fournier4
Estimated H-index: 4
(French Institute of Health and Medical Research),
Catherine Passirani37
Estimated H-index: 37
(French Institute of Health and Medical Research)
+ 3 AuthorsJean-Pierre Benoit66
Estimated H-index: 66
(French Institute of Health and Medical Research)
Abstract In order to treat malignant brain tumors by local delivery of antineoplastic agents, the feasibility of 5-fluorouracil (5-FU)-sustained release biodegradable microspheres with a novel material, poly(methylidene malonate 2.1.2), was investigated using an emulsion/extraction method. This polymer was expected to present a slow degradation rate, thus leading to a long term local delivery system. Microparticles were successfully obtained and characterized in terms of drug loading, size, morp...
53 Citations Source Cite
Published on Feb 1, 2009in Molecular Nutrition & Food Research 5.15
Peter Baade41
Estimated H-index: 41
(Queensland University of Technology),
Danny R. Youlden23
Estimated H-index: 23
(Cancer Council Queensland),
Lauren Krnjacki12
Estimated H-index: 12
(Cancer Council Queensland)
This review outlines current international patterns in prostate cancer incidence and mortality rates and survival, including recent trends and a discussion of the possible impact of prostate-specific antigen (PSA) testing on the observed data. Internationally, prostate cancer is the second most common cancer diagnosed among men (behind lung cancer), and is the sixth most common cause of cancer death among men. Prostate cancer is particularly prevalent in developed countries such as the United St...
283 Citations Source Cite
Published on Mar 1, 2011in Advanced Drug Delivery Reviews 13.66
Jun Fang24
Estimated H-index: 24
(Sojo University),
Hideaki Nakamura13
Estimated H-index: 13
(Sojo University),
Hiroshi Maeda20
Estimated H-index: 20
(Sojo University)
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors related to their anatomical and pathophysiological differences from normal tissues. For example, angiogenesis leads to high vascular density in solid tumors, large gaps exist between endothelial cells in tumor blood vessels, and tumor tissues show selective extravasation and retention of macromolecular drugs. This EPR effect served as a basis for development of macromolecular anticancer therapy. We demons...
1,508 Citations Source Cite
Published on Nov 1, 2014in Inorganica Chimica Acta 2.26
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Ngoc Trang Caroline Truong2
Estimated H-index: 2
(Florida Atlantic University)
+ 3 AuthorsNancy T. Trang5
Estimated H-index: 5
(University of Texas at Arlington)
Abstract Polyether esters are rapidly formed employing the interfacial condensation of organotin dihalides with glycyrrhetinic acid in high yield and oligomeric to polymeric chain length. Infrared spectroscopy shows the formation of tin–oxygen bonds. The products are a mixture of bridging and non-bridging structures about the tin atom. Proton NMR and MALDI MS results are consistent with the formation of the poly(ether esters). The dimethyltin, dibutyltin, and diphenyltin polymers exhibit good in...
7 Citations Source Cite
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Girish Barot11
Estimated H-index: 11
(Florida Atlantic University)
+ 1 AuthorsMichael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
The effect of solvent on the ability to inhibit a group of cell lines was studied employing a series of water-soluble dibutyltin polyethers derived from various hydroxyl-terminated poly(ethylene glycols). Molecular weight as a function of time was essentially unchanged for a period of 30 weeks for the polyethers. Variations in test media can affect biological activities on the cell level as well as at the molecular level. The current study involves the evaluation of the cellular effects when dim...
10 Citations Source Cite
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Girish Barot11
Estimated H-index: 11
(Boston University)
+ 2 AuthorsMichael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
The degradation of water soluble organotin polyether in the presence of trypsin was studied. The polymer was found to be stable to 4 days, the typical cancer cell line testing time. This is consistent with polymer activity against cancer cell lines being a result of the non-degraded chain and not controlled release of the organotin moiety. As a control trypsin activity was studied employing light scattering photometry and gel electrophoresis. The trypsin was active degrading bovine serine albumi...
12 Citations Source Cite
Cited By4
Published on Jul 2, 2016in Journal of Macromolecular Science, Part A 1.06
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 6 AuthorsLindsey Miller4
Estimated H-index: 4
(University of Texas at Arlington)
ABSTRACTWe describe the initial synthesis of DMSO and water-soluble titanocene polyethers through reaction of the titanocene dichloride and various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the titanocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1500 to 4. They exhibit good inhibition of a variety of cancer cell lines including two pancreatic cancer cell line...
4 Citations Source Cite
Published on Sep 1, 2016in Journal of Organometallic Chemistry 1.95
Khodayar Gholivand18
Estimated H-index: 18
(Tarbiat Modares University),
Rasoul Salami2
Estimated H-index: 2
(Tarbiat Modares University)
+ 1 AuthorsElham Torabi1
Estimated H-index: 1
(Tarbiat Modares University)
Abstract Two new diorganotin complexes with formula {SnCl 2 (CH 3 ) 2 L1} 2 (C1), L1 = N-nicotinyl, N′,N″-bis(diethylamine) phosphoric triamide and {SnCl 2 (CH 3 ) 2 L2} n (C2), L2 = N-nicotinyl, N′,N″-bis(cyclopentylamine) phosphoric triamide were synthesized and characterized by IR and NMR spectroscopy, and elemental analysis. Single crystal X-ray diffraction structural analyses confirmed all-trans and cis–trans configurations for distorted octahedral geometry in C1 and C2, respectively. Also,...
8 Citations Source Cite
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University),
Paul Slawek2
Estimated H-index: 2
(Florida Atlantic University)
+ 4 AuthorsFloyd Russell2
Estimated H-index: 2
(Florida Atlantic University)
The interfacial polymerization is employed to produce high polymer poly(ester ethers) from the reaction of the salt of dipicolinic acid and various organotin dihalides. They are rapidly synthesized with yield increasing as the length of the organotin alkyl chain increases. Infrared spectroscopy shows the formation of new bands derived from the Sn–O and Sn–O(CO) linkages. IR also shows that the products exist as a combination of molecular geometries about the tin atom. MALDI MS shows formation of...
3 Citations Source Cite
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 5 AuthorsPaul Slawek2
Estimated H-index: 2
(Florida Atlantic University)
Polyesters were rapidly synthesized employing interfacial polymerization from reaction of the salt of camphoric acid with Group VA (Group 15) triphenylmetallic dihalides. Yields range from 25 to 46 percent with chain lengths about 250. Infrared spectroscopy shows the formation of two new bands one assigned to the symmetrical M–O stretching and the second assigned to the asymmetrical M–O stretching. The bridging structure about the metal atom increases as the metal atom size increases. MALDI MS a...
2 Citations Source Cite