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The association of clot lysis time with total obesity is partly independent from the association of PAI-1 with central obesity in African adults

Published on Aug 1, 2015in Thrombosis Research3.266
· DOI :10.1016/j.thromres.2015.05.033
Philna Eksteen1
Estimated H-index: 1
(NWU: North-West University),
Marlien Pieters16
Estimated H-index: 16
(NWU: North-West University)
+ 1 AuthorsHerculina S. Kruger22
Estimated H-index: 22
(NWU: North-West University)
Abstract
Abstract Introduction Preliminary evidence indicates that the association of fibrinolytic potential, measured as clot lysis time (CLT), with body composition may differ from that of plasminogen activator inhibitor type-1 (PAI-1). We therefore investigated the association between fibrinolytic markers (plasminogen activator inhibitor type-1 activity (PAI-1 act ) and CLT) and body composition using detailed body composition analyses. Materials and methods Data from 1288 Africans were cross-sectionally analyzed. Body composition analysis included BMI, waist circumference (WC); waist to height ratio (WHtR), skinfolds and body fat percentage measured with air-displacement plethysmography and bioelectrical impedance analysis. Results PAI-1 act and CLT were significantly higher in women than in men, despite adjustment for differences in body composition. PAI-1 act and CLT showed similar linear positive relationships with body composition (BMI, WC, WHtR, skinfolds) in men. In women CLT also showed a linear relationship with body composition, while PAI-1 act levels plateaued at higher BMI and did not differ across skinfold categories. PAI-1 act showed stronger correlations with body composition markers in men than it did in women, while no sex differences existed for CLT. PAI-1 act associated more strongly with central obesity, while CLT associated with total body fat. Conclusions Observed differences may be related to differences in adipose tissue type, distribution and sequence of accumulation between sexes. PAI-1 act is strongly influenced by accumulation of visceral adipose tissue, whereas CLT is associated with obesity independent of type and sequence of body fat accumulation in this African adult study population.
  • References (43)
  • Citations (5)
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References43
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#1Lisa J. Ware (Health Sciences North)H-Index: 12
#2Kirsten L. Rennie (University of Hertfordshire)H-Index: 22
Last. Aletta E. Schutte (Health Sciences North)H-Index: 44
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Abstract Background and aims Simple, low-cost central obesity measures may help identify individuals with increased cardiometabolic disease risk, although it is unclear which measures perform best in African adults. We aimed to: 1) cross-sectionally compare the accuracy of existing waist-to-height ratio (WHtR) and waist circumference (WC) thresholds to identify individuals with hypertension, pre-diabetes, or dyslipidaemia; 2) identify optimal WC and WHtR thresholds to detect CVD risk in this Afr...
30 CitationsSource
#1Marlien Pieters (NWU: North-West University)H-Index: 16
#2Hendriek C. Boshuizen (WUR: Wageningen University and Research Centre)H-Index: 25
Last. Robert A. S. Ariëns (University of Leeds)H-Index: 41
view all 7 authors...
Abstract Introduction Although both coagulation and fibrinolysis are associated with cardiovascular disease (CVD) the underlying nature and pathways of many of these associations are still unclear. Our aim was to determine which of the current or 5-year prior levels of total fibrinogen, fibrinogen γ’, plasminogen activator inhibitor-1 (PAI-1act) and global fibrinolytic potential were the stronger determinant of arterial structure and function. Materials and methods This prospective study consist...
4 CitationsSource
#1Marlien PietersH-Index: 16
#2Retha C. M. KotzeH-Index: 4
Last. Robert A. S. Ariëns (University of Leeds)H-Index: 41
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Fibrinogen γ′ is known to influence fibrin clot structure in purified experimental models, but little is known regarding its influence on clot structure in plasma. Furthermore, the environmental and biological factors that affect its concentration are poorly described. We analyzed fibrinogen
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#2Iwan-Zietek IH-Index: 4
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#1Zelda de Lange (NWU: North-West University)H-Index: 6
#2Marlien Pieters (NWU: North-West University)H-Index: 16
Last. Dingeman C. Rijken (EUR: Erasmus University Rotterdam)H-Index: 24
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Studies in populations of European descent show longer plasma clot lysis times (CLT) in patients with cardiovascular disease (CVD) than in controls. No data are available on the association between CVD risk factors and fibrinolytic potential in black Africans, a group undergoing rapid urbanisation with increased CVD prevalence. We investigated associations between known CVD risk factors and CLT in black Africans and whether CLTs differ between rural and urban participants in light of differences...
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#2Vinay Pasupuleti (Cleveland Clinic)H-Index: 19
Last. J. Jaime Miranda (UPCH: Cayetano Heredia University)H-Index: 34
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Context Limited information is available of effects of rural-to-urban within-country migration on cardiovascular (CV) risk factors in low- and middle- income countries (LMIC). Objective A systematic review of studies evaluating these effects was performed with rural and/or urban control groups. Study selection Two teams of investigators searched observational studies in Medline, Web of Science and Scopus until May 2011. Studies evaluating international migration were excluded. Data extraction Th...
42 CitationsSource
#1Florian Prüller (Medical University of Graz)H-Index: 13
#2Reinhard B. Raggam (Medical University of Graz)H-Index: 25
Last. Harald Mangge (Medical University of Graz)H-Index: 32
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Abstract Objective Endogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism. Methods Three hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16–58years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance ® ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulat...
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#1Shona Dalal (Harvard University)H-Index: 12
#2Juan Jose BeunzaH-Index: 1
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Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain, Faculty of Health Sciences, Stellenbosch University, Stellenbosch, South Africa, Institute of Human Virology, Abuja, Nigeria, School of Medicine Greenbaum Cancer Center and Institute of Human Virology, University of Maryland, Baltimore, MD, USA, Department of Community Health, Mbarara University Of Science and Technology, Mbara...
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#1Ayesha A. MotalaH-Index: 24
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OBJECTIVE To determine the prevalence of metabolic syndrome and to define optimal ethnic-specific waist-circumference cutoff points in a rural South African black community. RESEARCH DESIGN AND METHODS This was a cross-sectional survey conducted by random-cluster sampling of adults aged >15 years. Participants had demographic, anthropometric, and biochemical measurements taken, including a 75-g oral glucose tolerance test. Metabolic syndrome was defined using the 2009 Joint Interim Statement (JI...
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Last. Julia H. Goedecke (Medical Research Council)H-Index: 30
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Waist circumference (WC) is used independently and as a component of the metabolic syndrome to predict cardiovascular disease and type 2 diabetes mellitus (1). Since body fat distribution is different between blacks and whites (2, 3) and the prevalence of cardiovascular disease, type 2 diabetes mellitus, and even hypertension and obesity is higher in blacks than whites, the WC of risk may not be the same in blacks and whites (4, 5) Yet due to a lack of data in blacks, it is the practice of the I...
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Cited By5
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Abstract Evidence regarding the relationship of plasma clot properties with fatty acids is contradictory, owing to different experimental protocols employed. The relationship of fibrinogen and plasma fibrin clot properties with plasma phospholipid fatty acids were cross-sectionally investigated in a population-based setting in 900 individuals. Composite saturated fatty acids (driven by stearic acid) and composite n-3 and n-6 polyunsaturated fatty acids (driven by docosahexaenoic and arachidonic ...
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#1Hao Peng (UF: University of Florida)H-Index: 4
#2Fawn YehH-Index: 11
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Deficient plasminogen activator inhibitor-1 (PAI-1) prevented hypertension in mice. Plasma PAI-1 was associated with hypertension in cross-sectional analyses, but the prospective association of PAI-1 with incident hypertension in large epidemiological studies is scarce. Leveraging two longitudinal cohorts of American Indians in the Strong Heart Study (SHS, N = 1019) and the Strong Heart Family Study (SHFS, N = 1502), we examined the prospective association of plasma PAI-1 with incident hypertens...
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#1Hao Peng (UF: University of Florida)H-Index: 4
#2Fawn Yeh (University of Oklahoma Health Sciences Center)H-Index: 11
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Essentials Plasminogen activator inhibitor-1 (PAI-1) advanced cellular senescence in experiment studies. No population study exists on the association between PAI-1 and biological aging in American Indians. We found cross-sectional and longitudinal associations between higher PAI-1 and shorter telomere length. Our findings suggest a pathway linking PAI-1 with biological aging beyond metabolic factors. SummaryBackground Plasminogen activator inhibitor-1 (PAI-1) promotes cellular aging both in vit...
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#1Sunelle A. Barnard (NWU: North-West University)H-Index: 3
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Increased plasma plasminogen activator inhibitor-1 (PAI-1) level is considered a mechanistic pathway through which obesity contributes to increased cardiovascular disease risk. Abdominal adipose tissue specifically, is a major PAI-1 source with visceral adipose tissue (VAT), an ectopic fat depot, generally considered to produce more PAI-1 than subcutaneous adipose tissue. However, this does not necessarily lead to increased plasma PAI-1 levels. This review provides an overview of studies investi...
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Adipose tissue has recently been reevaluated as an endocrine organ, and adipose-tissue-derived endocrine factors are termed adipokines. Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of PAs, which convert plasminogen into plasmin, a critical protease involved in fibrinolysis. PAI-1 induces fibrinogenesis by suppressing intravascular and tissue fibrinolysis. Moreover, PAI-1 exerts various cellular effects independently of fibrinolysis. Although PAI-1 is expressed in various ti...
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