Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes.

Volume: 16, Issue: 11, Pages: 665 - 677
Published: Nov 1, 2015
Abstract
Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade mRNAs with translation termination codons that are positioned in abnormal contexts. However, NMD is not only part of a general cellular quality control system that prevents the production of aberrant proteins. Mammalian cells also depend on NMD to dynamically adjust their...
Paper Details
Title
Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes.
Published Date
Nov 1, 2015
Volume
16
Issue
11
Pages
665 - 677
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