Quantitation of chondroitin 4-sulfate and chondroitin 6-sulfate in pathologic joint fluid

Objective . To investigate the correlation between joint disease and the composition of chondroitin sulfate in the joint fluid, unsaturated disaccharide isomers of chondroitin 4—sulfate (Δdi‐4S) and chondroitin 6—sulfate (Δdi‐6S) were measured in joint fluids obtained from patients with osteoarthritis (OA), rheumatoid arthritis (RA), or traumatic arthritis (TA). Methods . These pathologic joint fluids were digested with chondroitinase ABC, and...