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Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus.

Published on Jan 1, 2015in Chemical & Pharmaceutical Bulletin1.405
· DOI :10.1248/cpb.c15-00192
Yoshinori Onuki15
Estimated H-index: 15
(Hoshi University),
Yoshiaki Machida6
Estimated H-index: 6
(Hoshi University)
+ 3 AuthorsKozo Takayama47
Estimated H-index: 47
(Hoshi University)
Abstract
  • References (1)
  • Citations (4)
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References1
Newest
#1Anuj Shukla (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 6
#2Martin Janich (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 12
Last. Reinhard H.H. Neubert (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 38
view all 6 authors...
Purpose. Stable oil/water (o/w) microemulsions are very effective vehicle systems for dermal administration of drugs having no or low skin penetration. These systems, consisting of oils, a blend of a high and a low HLB surfactant, and a hydrophilic phase (propylene glycol/water), were developed using pharmaceutically acceptable components.
30 CitationsSource
Cited By4
Newest
#1Takahiro Tsuji (University of Toyama)H-Index: 1
#2Koji Mochizuki (Hoshi University)
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 7 authors...
Abstract The time–temperature superposition principle (TTSP) was applied to the destabilization kinetics of a pharmaceutical emulsion. The final goal of this study is to predict precisely the emulsion stability after long-term storage from the short-period accelerated test using TTSP. As the model emulsion, a cream preparation that is clinically used for the treatment of pruritus associated with chronic kidney disease was tested. After storage at high temperatures ranging from 30 to 45 °C for de...
Source
#1Yoshinori Onuki (University of Toyama)H-Index: 15
#2Chiaki Funatani (Hoshi University)H-Index: 2
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 7 authors...
Source
#1Yoshinori Onuki (University of Toyama)H-Index: 15
#2Masamitsu Yokokawa (Hoshi University)H-Index: 1
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 8 authors...
1 CitationsSource
#1Yoshinori Onuki (University of Toyama)H-Index: 15
#2Chihiro Kida (Hoshi University)H-Index: 3
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 5 authors...
We have recently established a novel method to evaluate the emulsion stability of pharmaceutical skin cream. The key technology of the method is magnetic resonance imaging (MRI). The purpose of this study was to verify the usefulness of the method in the cosmetic industry.Milky lotion-type emulsions were employed as test samples. We note that the test samples were prepared by taking account of commercial milky lotions. After the sample preparation, a centrifugation treatment (5000 g for up to 12...
6 CitationsSource