Magnetic resonance imaging study on the physical stability of menthol and diphenhydramine cream for the treatment of chronic kidney disease-associated pruritus.

Published on Jan 1, 2015in Chemical & Pharmaceutical Bulletin1.405
· DOI :10.1248/cpb.c15-00192
Yoshinori Onuki15
Estimated H-index: 15
(Hoshi University),
Yoshiaki Machida6
Estimated H-index: 6
(Hoshi University)
+ 3 AuthorsKozo Takayama47
Estimated H-index: 47
(Hoshi University)
  • References (1)
  • Citations (4)
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Abstract The time–temperature superposition principle (TTSP) was applied to the destabilization kinetics of a pharmaceutical emulsion. The final goal of this study is to predict precisely the emulsion stability after long-term storage from the short-period accelerated test using TTSP. As the model emulsion, a cream preparation that is clinically used for the treatment of pruritus associated with chronic kidney disease was tested. After storage at high temperatures ranging from 30 to 45 °C for de...
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We have recently established a novel method to evaluate the emulsion stability of pharmaceutical skin cream. The key technology of the method is magnetic resonance imaging (MRI). The purpose of this study was to verify the usefulness of the method in the cosmetic industry.Milky lotion-type emulsions were employed as test samples. We note that the test samples were prepared by taking account of commercial milky lotions. After the sample preparation, a centrifugation treatment (5000 g for up to 12...
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