Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio‐resistance in breast cancer
Abstract
Radiation‐induced DNA damage activates the DNA damage response (DDR). DDR up‐regulation may predict radio‐resistance and increase the risk of early local recurrence despite radiotherapy in early stage breast cancers. In 1755 early stage breast cancers, DDR signalling [ATM, ATR, total Ckh1, Chk1 phosphorylated at serine345 (pChk1), Chk2, p53], base excision repair [PARP1, POLβ, XRCC1, FEN1, SMUG1], non‐homologous end joining (Ku70/Ku80, DNA‐PKcs)...
Paper Details
Title
Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio‐resistance in breast cancer
Published Date
Oct 3, 2015
Journal
Volume
10
Issue
2
Pages
213 - 223
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