New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins
Abstract
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. Inosine can have a profound effect on the RNAs that are edited, not only changing the base-pairing properties, but can also result in recoding, as inosine behaves as if it were guanosine. In mammals there are three ADAR proteins and two ADAR-related proteins (ADAD) expressed. All have a very similar...
Paper Details
Title
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins
Published Date
Sep 30, 2015
Journal
Volume
5
Issue
4
Pages
2338 - 2362
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