Effect of amyloid‐β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)‐3β

Aims Active amyloid‐β ( A β) immunotherapy in Alzheimer's disease ( AD ) induces removal of Aβ and phosphorylated tau (ptau). Glycogen synthase kinase ( GSK )‐3β is a kinase, responsible for phosphorylation of tau, activation of which can be induced by phosphorylated double‐stranded RNA ‐dependent protein kinase (p PKR ). Using a post‐mortem cohort of immunized AD cases, we investigated the effect of A β immunization on GSK ‐3β expression and p...