STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

Volume: 18, Issue: 2, Pages: 157 - 168
Published: Aug 12, 2015
Abstract
STING is an ER-associated membrane protein that is critical for innate immune sensing of pathogens. STING-mediated activation of the IFN-I pathway through the TBK1/IRF3 signaling axis involves both cyclic-dinucleotide binding and its translocation from the ER to vesicles. However, how these events are coordinated, and the exact mechanism of STING activation, remain poorly understood. Here, we found that the Shigella effector protein IpaJ...
Paper Details
Title
STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease
Published Date
Aug 12, 2015
Volume
18
Issue
2
Pages
157 - 168
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