Metformin induces PGC‐1α expression and selectively affects hepatic PGC‐1α functions

Background and Purpose The objective of this study was to determine how the AMPK activating antidiabetic drug metformin affects the major activator of hepatic gluconeogenesis, PPARγ coactivator 1α ( PGC ‐1α) and liver functions regulated by PGC ‐1α. Experimental Approach Mouse and human primary hepatocytes and mice in vivo were treated with metformin. Adenoviral overexpression, siRNA and reporter gene constructs were used for mechanistic...