Population pharmacokinetics of levodopa in subjects with advanced Parkinson's disease: levodopa‐carbidopa intestinal gel infusion vs. oral tablets

Levodopa-carbidopa intestinal gel (LCIG) provides continuous levodopa-carbidopa delivery through intrajejunal infusion. This study characterized the population pharmacokinetics of levodopa following a 16 h jejunal infusion of LCIG or frequent oral administration of levodopa-carbidopa tablets (LC-oral) in subjects with advanced Parkinson's disease (PD).A non-linear mixed-effects model of levodopa pharmacokinetics was developed using serial plasma...