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Tissue engineering in urology

Published on May 1, 2013in Cuaj-canadian Urological Association Journal1.253
· DOI :10.5489/cuaj.1155
Derek J. Matoka8
Estimated H-index: 8
(Children's Memorial Hospital),
Earl Y. Cheng20
Estimated H-index: 20
(Children's Memorial Hospital)
Abstract
Tissue engineering encompasses a multidisciplinary approach geared toward the development of biological substitutes designed to restore and maintain normal function in diseased or injured tissues. This article reviews the basic technology that is used to generate implantable tissue-engineered grafts in vitro that will exhibit characteristics in vivo consistent with the physiology and function of the equivalent healthy tissue. We also examine the current trends in tissue engineering designed to tailor scaffold construction, promote angiogenesis and identify an optimal seeded cell source. Finally, we describe several currently applied therapeutic modalities that use a tissue-engineered construct. While notable progress has clearly been demonstrated in this emerging field, these efforts have not yet translated into widespread clinical applicability. With continued development and innovation, there is optimism that the tremendous potential of this field will be realized. L’ingenierie tissulaire englobe une approche multidisciplinaire axee sur le developpement de substituts biologiques en vue de retablir et de maintenir la fonction normale de tissus leses. L’article qui suit passe en revue la technologie fondamentale utilisee pour generer des greffons implantables produits par ingenierie in vitro et possedant des caracteristiques in vivo correspondant aux tissus sains equivalents sur les plans physiologique et fonctionnel. Nous examinons egalement les tendances actuelles en ingenierie tissulaire visant a adapter des echafaudages tissulaires, a promouvoir l’angiogenese et a degager une source optimale de cellules implantables. Enfin, nous decrivons plusieurs modalites therapeutiques actuellement mises en application utilisant un echafaudage cree par ingenierie tissulaire. En depit de progres remarquables dans ce domaine en effervescence, les efforts deployes ne se sont pas encore traduits par une applicabilite clinique etendue. Des developpements et des percees continus permettent d’etre optimiste face au potentiel prodigieux de ce domaine.
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