Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells
Abstract
Type 2 innate lymphoid cells (ILC2s) promote anti-helminth responses and contribute to allergies. Here, we report that Bcl11b, previously considered a T-cell-specific transcription factor, acted directly upstream of the key ILC2 transcription factor Gfi1 to maintain its expression in mature ILC2s. Consequently, Bcl11b(-/-) ILC2s downregulated Gata3 and downstream genes, including Il1rl1 (encoding IL-33 receptor), and upregulated Rorc and type 3...
Paper Details
Title
Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells
Published Date
Aug 1, 2015
Journal
Volume
43
Issue
2
Pages
354 - 368
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