Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

Volume: 17, Issue: 6, Pages: 759 - 770
Published: Jun 1, 2015
Abstract
Chaperone-mediated autophagy (CMA) selectively degrades a subset of cytosolic proteins in lysosomes. A potent physiological activator of CMA is nutrient deprivation, a condition in which intracellular triglyceride stores or lipid droplets (LDs) also undergo hydrolysis (lipolysis) to generate free fatty acids for energetic purposes. Here we report that the LD-associated proteins perilipin 2 (PLIN2) and perilipin 3 (PLIN3) are CMA substrates and...
Paper Details
Title
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
Published Date
Jun 1, 2015
Volume
17
Issue
6
Pages
759 - 770
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