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Results of the DSM-IV Mood Disorders Field Trial

Published on Jan 1, 1995in American Journal of Psychiatry 13.65
· DOI :10.1176/ajp.152.6.843
Martin B. Keller116
Estimated H-index: 116
(Butler Hospital),
Daniel N. Klein72
Estimated H-index: 72
(Butler Hospital)
+ 8 AuthorsT. Shea1
Estimated H-index: 1
(Butler Hospital)
Objective: The DSM-IV mood disorders field trial, a multisite collaborative study, was designed to explore the reliability of a course-based diagnostic classification system for major depression, evaluate the symptom criteria for dysthymia, and explore the need for additional diagnostic categories for milder forms of mood disorder (e.g., minor and recurrent brief depression). Method : Five hundred twenty-four depressed subjects were recruited from inpatient, outpatient, and community settings at five sites and evaluated with structured interviews according to DSM-III and DSM-III-R criteria, with careful attention to longitudinal course. Within- and across-site interrater reliability studies and 6-month test-retest reliability studies were also conducted on subsets of the sample. Results : For evaluations of major depression and dysthymia, intrasite reliability was good to excellent and intersite reliability was fair to good ; 6-month test-retest reliability was fair for dysthymia and poor to fair for major depression. Interrater reliability for six course of illness specifiers was fair to good, and almost all subjects could be assigned to a specific type of course. Conclusions : The results supported the use of course-based classification system for major depression. They also suggested that the content validity of the DSM-III-R symptom criteria for dysthymia could be improved by emphasizing cognitive and social/motivational symptoms, although such changes are unlikely to sharpen the distinction between dysthymia and major depression. Finally, 91% of the subjects met the criteria for current or lifetime major depression or dysthymia, suggesting that additional categories for milder forms of depression are not needed.
  • References (14)
  • Citations (199)
Published on Oct 1, 1992in Archives of General Psychiatry
Kenneth B. Wells86
Estimated H-index: 86
M. Audrey Burnam55
Estimated H-index: 55
+ 2 AuthorsPatti Camp7
Estimated H-index: 7
• Objective.— To compare the course of depression during a 2-year period in adult outpatients (n=626) with current major depression, dysthymia, and either both current disorders ("double depression") or depressive symptoms with no current depressive disorder. Methods.— Depressed patients visiting 523 clinicians (mental health specialists and general medical providers) were identified using a two-stage screening procedure including the Diagnostic Interview Schedule. The course of depression was a...
406 Citations Source Cite
Published on Aug 1, 1992in Archives of General Psychiatry
Janet B. W. Williams9
Estimated H-index: 9
(MPG: Max Planck Society),
Miriam Gibbon15
Estimated H-index: 15
(MPG: Max Planck Society)
+ 8 AuthorsBruce J. Rounsaville90
Estimated H-index: 90
(MPG: Max Planck Society)
• A test-retest reliability study of the Structured Clinical Interview for DSM-III-R was conducted on 592 subjects in four patient and two nonpatient sites in this country as well as one patient site in Germany. For most of the major categories, ks for current and lifetime diagnoses in the patient samples were above.60, with an overall weighted k of.61 for current and.68 for lifetime diagnoses. For the nonpatients, however, agreement was considerably lower, with a mean k of.37 for current and.51...
1,260 Citations Source Cite
Published on Jan 1, 1991in British Journal of Psychiatry 7.23
Declan G M Murphy D G M74
Estimated H-index: 74
('KCL': King's College London)
10 Citations Source Cite
Published on Jun 1, 1990in Journal of Affective Disorders 4.08
Jules Angst81
Estimated H-index: 81
Kathleen R. Merikangas102
Estimated H-index: 102
+ 1 AuthorsW. Wicki1
Estimated H-index: 1
(Yale University)
Abstract This paper presents the diagnostic criteria for a new subtype of affective disorder, recurrent brief depression (RBD). Data from a prospective longitudinal cohort of young adults from the general population of Zurich, Switzerland, showed that a substantial proportion, met all of the criteria for major depression in current diagnostic systems except duration. The validity of the subtype of RBD was examined according to clinical manifestations, severity, longitudinal course, and family hi...
165 Citations Source Cite
Published on Dec 1, 1988in British Journal of Psychiatry 7.23
Alan S. Lee8
Estimated H-index: 8
Robin M. Murrayand143
Estimated H-index: 143
Eighty-nine consecutive admissions with primary depressive illness were prospectively ascertained and diagnosed in 1965-66 by R. E. Kendell, who also allocated each a position on a neurotic-psychotic continuum on the basis of previous discriminant function analysis. In 1983-84, 94% of the survivors were personally interviewed by a psychiatrist blind to index admission data. Operational outcome criteria were employed and longitudinal data were established for 98% of the series. Mortality risk was...
251 Citations Source Cite
Published on Dec 1, 1987in American Journal of Psychiatry 13.65
Kocsis Jh1
Estimated H-index: 1
Frances Aj1
Estimated H-index: 1
91 Citations Source Cite
Published on Feb 1, 1987in Archives of General Psychiatry
Michael Von Korff115
Estimated H-index: 115
(Group Health Cooperative),
Sam Shapiro43
Estimated H-index: 43
(Johns Hopkins University)
+ 5 AuthorsBarbara J. Burns72
Estimated H-index: 72
(NIH: National Institutes of Health)
• Over one half of all persons seen in a primary care clinic were identified as having anxiety or depressive disorder by the primary care provider, the General Health Questionnaire (GHQ), or the Diagnostic Interview Schedule (DIS). In only about 5% of all patients were findings positive on all three assessments concurrently. Both the GHQ and the practitioners identified over 30% of all patients as having a disorder, while about 8% had one or more of five DIS anxiety or depressive disorders (majo...
320 Citations Source Cite
Published on Jan 1, 1986in American Journal of Psychiatry 13.65
Martin B. Keller116
Estimated H-index: 116
(Harvard University),
Phil Lavori82
Estimated H-index: 82
(Harvard University)
+ 2 AuthorsRobert M. A. Hirschfeld72
Estimated H-index: 72
199 Citations Source Cite
Published on Feb 1, 1985in Acta Psychiatrica Scandinavica 4.69
Peter Roy-Byrne1
Estimated H-index: 1
Robert M. Post1
Estimated H-index: 1
+ 2 AuthorsDebra Davis1
Estimated H-index: 1
295 Citations Source Cite
Cited By199
Published on Apr 27, 2019in Pilot and Feasibility Studies
Barnaby D. Dunn26
Estimated H-index: 26
(University of Exeter),
Emily Widnall (University of Exeter)+ 14 AuthorsKim Wright13
Estimated H-index: 13
(University of Exeter)
Background While existing psychological treatments for depression are effective for many, a significant proportion of depressed individuals do not respond to current approaches and few remain well over the long-term. Anhedonia (a loss of interest or pleasure) is a core symptom of depression which predicts a poor prognosis but has been neglected by existing treatments. Augmented Depression Therapy (ADepT) has been co-designed with service users to better target anhedonia alongside other features ...
2 Citations Source Cite
Published on Jun 1, 2019in Brain Sciences
Source Cite
Published on Jan 1, 2019in Neuron 14.40
Laith Alexander1
Estimated H-index: 1
(University of Cambridge),
Philip L.R. Gaskin (University of Cambridge)+ 5 AuthorsAngela C. Roberts45
Estimated H-index: 45
(University of Cambridge)
Summary Anhedonia is a core symptom of depression, but the underlying neurobiological mechanisms are unknown. Correlative neuroimaging studies implicate dysfunction within ventromedial prefrontal cortex, but the causal roles of specific subregions remain unidentified. We addressed these issues by combining intracerebral microinfusions with cardiovascular and behavioral monitoring in marmoset monkeys to show that over-activation of primate subgenual anterior cingulate cortex (sgACC, area 25) blun...
Source Cite
Published on Aug 1, 2018in Journal of Psychosomatic Research 2.72
Chenghao Yang2
Estimated H-index: 2
Kim M. Tiemessen1
Estimated H-index: 1
(UG: University of Groningen)
+ 3 AuthorsRobert A. Schoevers48
Estimated H-index: 48
OBJECTIVE: The current diagnostic criteria for major depressive disorder (MDD) do not allow prediction of prognosis and therapeutic response. A possible strategy to improve this situation is the identification of depression subtypes on the bases of biomarkers reflecting underlying pathological processes such as neuro-inflammation. METHODS: The PubMed/Medline database was searched until Apr 25th, 2017. In the initial search 1018 articles were retrieved, which were subsequently screened and only s...
5 Citations Source Cite
Published on Aug 1, 2018in Nature Reviews Neuroscience 33.16
Masud Husain65
Estimated H-index: 65
(John Radcliffe Hospital),
Jonathan P. Roiser43
Estimated H-index: 43
(UCL: University College London)
Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The fi...
10 Citations Source Cite
Published on Mar 1, 2018in Pediatrics 5.40
Rachel A. Zuckerbrot1
Estimated H-index: 1
(CUMC: Columbia University Medical Center),
Amy Cheung25
Estimated H-index: 25
(U of T: University of Toronto)
+ 2 AuthorsDanielle Laraque1
Estimated H-index: 1
(State University of New York Upstate Medical University)
OBJECTIVES: To update clinical practice guidelines to assist primary care (PC) clinicians in the management of adolescent depression. This part of the updated guidelines is used to address practice preparation, identification, assessment, and initial management of adolescent depression in PC settings. METHODS: By using a combination of evidence- and consensus-based methodologies, guidelines were developed by an expert steering committee in 2 phases as informed by (1) current scientific evidence ...
16 Citations Source Cite
Published on Feb 1, 2018in Molecular Psychiatry 11.97
R Bansal1
Estimated H-index: 1
D J Hellerstein1
Estimated H-index: 1
Bradley S. Peterson76
Estimated H-index: 76
Evidence for neuroplastic compensation in the cerebral cortex of persons with depressive illness
6 Citations Source Cite
Published on Jan 1, 2018in Behavioural Brain Research 2.77
Tong Wang3
Estimated H-index: 3
(Ministry of Science and Technology),
Cuige Shi6
Estimated H-index: 6
+ 8 AuthorsHui Li7
Estimated H-index: 7
(Capital Medical University)
Abstract Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders. Recent clinical studies suggest that OXT might also act as antidepressant in postpartum depression (PPD) patients, but the mechanism is still unknown. In the present study, we explored the effect of OXT in paraventricular nucleus (PVN) and possible signaling pathway involved in a PPD rat model induced by gestation restraint stress (GRS). PPD rats exhibited depressive-like beha...
10 Citations Source Cite
Published on Dec 1, 2017in Asian Journal of Psychiatry
Taichi Mogi2
Estimated H-index: 2
(National Defense Medical College),
Hiroyuki Toda11
Estimated H-index: 11
(National Defense Medical College),
Aihide Yoshino18
Estimated H-index: 18
(National Defense Medical College)
Abstract Background Physicians do not always confidently diagnose psychiatric disorders. The present study was conducted to identify the clinical characteristics of patients in whom a definitive diagnosis of major depressive disorder (MDD) could not be established. Methods The participants were 199 consecutive outpatients with MDD, who were comprehensively diagnosed using the Mini International Neuropsychiatric Interview (MINI). The physician in charge of each patient quantified his/her sense of...
2 Citations Source Cite