mTOR inhibitors counteract tamoxifen-induced activation of breast cancer stem cells
Abstract
Breast cancer cells with stem cell characteristics (CSC) are a distinct cell population with phenotypic similarities to mammary stem cells. CSCs are important drivers of tumorigenesis and the metastatic process. Tamoxifen is the most widely used hormonal therapy for estrogen receptor (ER) positive cancers. In our study, tamoxifen was effective in reducing proliferation of ER + adherent cancer cells, but not their CSC population. We isolated,...
Paper Details
Title
mTOR inhibitors counteract tamoxifen-induced activation of breast cancer stem cells
Published Date
Oct 1, 2015
Journal
Volume
367
Issue
1
Pages
76 - 87
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