Pharmacokinetics of continuous-release carbidopa/levodopa.

Volume: 17
Published: Jan 1, 1994
Abstract
This article reviews the pharmacokinetics of Sinemet CR, a controlled-release (CR) levodopa preparation. The main influences on the kinetic profile are as follows: absorption, which depends on the dissolution characteristics of the tablet, the pattern of gastric emptying, and the rate of uptake in the small intestine; distribution, which is determined by rates of levodopa transport from gut to blood and from blood to brain; and...
Paper Details
Title
Pharmacokinetics of continuous-release carbidopa/levodopa.
Published Date
Jan 1, 1994
Volume
17
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