Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV
Abstract
The DNA-end-joining reactions used for repair of double-strand breaks in DNA and for V(D)J recombination, the process by which immunoglobulin and T-cell antigen-receptor genes are assembled from multiple gene segments, use common factors. These factors include components of DNA-dependent protein kinase (DNA-PK), namely DNA-PKcs and the Ku heterodimer, Ku70-Ku80, and XRCC4. The precise function of XRCC4 is unknown, but it interacts with DNA...
Paper Details
Title
Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV
Published Date
Nov 1, 1998
Journal
Volume
396
Issue
6707
Pages
173 - 177
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