Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry
Volume: 112, Issue: 29
Published: Jul 8, 2015
Abstract
Herpes simplex virus (HSV) is an important human pathogen. It enters cells through an orchestrated process that requires four essential glycoproteins, gD, gH/gL, and gB, activated in cascade fashion by receptor-binding and signaling. gH/gL heterodimer is conserved across the Herpesviridae family. HSV entry is enabled by gH/gL interaction with αvβ6- or αvβ8-integrin receptors. We report that the interaction of virion gH/gL with integrins resulted...
Paper Details
Title
Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry
Published Date
Jul 8, 2015
Volume
112
Issue
29
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