STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells

Volume: 193, Issue: 12, Pages: 6124 - 6134
Published: Dec 15, 2014
Abstract
Adaptive immune responses to Ags released by dying cells play a critical role in the development of autoimmunity, allograft rejection, and spontaneous as well as therapy-induced tumor rejection. Although cell death in these situations is considered sterile, various reports have implicated type I IFNs as drivers of the ensuing adaptive immune response to cell-associated Ags. However, the mechanisms that underpin this type I IFN production are...
Paper Details
Title
STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells
Published Date
Dec 15, 2014
Volume
193
Issue
12
Pages
6124 - 6134
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