Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations
Abstract
Mutations in the presenilin‐1 (PS1) gene cause early onset familial Alzheimer's disease (FAD) by a mechanism believed to involve perturbed endoplasmic reticulum (ER) function and altered proteolytic processing of the amyloid precursor protein. We investigated the molecular mechanisms underlying cell death and ER dysfunction in cultured cells and knock‐in mice expressing FAD PS1 mutations. We report that PS1 mutations cause a marked increase in...
Paper Details
Title
Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations
Published Date
Oct 17, 2002
Journal
Volume
83
Issue
3
Pages
673 - 681
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History