Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2A

Volume: 112, Issue: 37, Pages: 11612 - 11617
Published: Aug 24, 2015
Abstract
Significance Epstein–Barr virus (EBV) is a human herpesvirus that establishes persistent infection of the B-cell compartment. EBV is associated with autoimmune diseases, including systemic lupus erythematosus (SLE). However, the molecular mechanisms by which EBV contributes to autoimmunity remain unclear. We used previously undescribed mouse models to study the role of EBV-encoded latent membrane protein 2A (LMP2A), which mimics B-cell receptor...
Paper Details
Title
Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2A
Published Date
Aug 24, 2015
Volume
112
Issue
37
Pages
11612 - 11617
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