Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts is associated with loss of adhesion molecule and pro-invasive ECM species transcripts

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA 3032 Disease progression of high grade glioma involves a complex interplay between tumor cells and the peri-tumor microenvironment. Predilection of glioma cells to invade locally is problematic in that dispersing cells are less sensitive to radiotherapy and chemotherapeutics. Focal adhesion kinases (FAK and Pyk2) are important functional modifiers of glioma; Pyk2 exerts pro-migratory and...