Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection.

Volume: 10, Issue: 6
Published: Jun 8, 2015
Abstract
Genome editing technologies, especially the Cas9/CRISPR system, have revolutionized biomedical research over the past several years. Generation of novel alleles has been simplified to unprecedented levels, allowing for rapid expansion of available genetic tool kits for researchers. However, the issue of genotypic mosaicism has become evident, making stringent analyses of the penetrance of genome-edited alleles essential. Here, we report that...
Paper Details
Title
Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection.
Published Date
Jun 8, 2015
Journal
Volume
10
Issue
6
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