The Roles of Dopamine Transport Inhibition and Dopamine Release Facilitation in Wake Enhancement and Rebound Hypersomnolence Induced by Dopaminergic Agents

Sleep5.60
Volume: 32, Issue: 11, Pages: 1425 - 1438
Published: Nov 1, 2009
Abstract
ALTHOUGH THE REGULATION OF SLEEP AND WAKE STATES IS BELIEVED TO INVOLVE BRAIN DOPAMINE (DA),1–3 ITS ROLE APPEARS COMPLEX. ACTIVATION of dopamine D1 receptors increases wake and reduces rapid eye movement sleep (REMS).4 The effects of activation of dopamine D2 receptors depend on dose and location.5 While D1 and D2 receptor agonists injected into intracerebral ventricles can increase wake,6 microinjection of mixed D1/D2 receptor agonists (e.g.,...
Paper Details
Title
The Roles of Dopamine Transport Inhibition and Dopamine Release Facilitation in Wake Enhancement and Rebound Hypersomnolence Induced by Dopaminergic Agents
Published Date
Nov 1, 2009
Journal
Volume
32
Issue
11
Pages
1425 - 1438
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