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50Sn Tin Compounds and Their Therapeutic Potential

Published on Dec 20, 2005
· DOI :10.1002/0470864052.ch22
Marcel Gielen35
Estimated H-index: 35
(Vrije Universiteit Brussel),
Edward R. T. Tiekink53
Estimated H-index: 53
(NUS: National University of Singapore)
Abstract
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  • Citations (55)
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#1Anup Paul (IST: Instituto Superior Técnico)H-Index: 15
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A novel Sn(IV) meso-tetraacenaphthylporphyrin (SnTAcP) has been synthesized and characterized. SnTAcP was complexed with methyl-β-cyclodextrin (mβ-CD), a nanocarrier that enhances water solubility,...
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Interactions of tributyltin (TBTA) and triphenyltin (TPhTA) 2-[4 (dimethylamino)phenylazo]benzoates, showing promising cytostatic activity against tumor cells, with erythrocytes and with erythrocyte membranes and model lipid membranes have been investigated. The effect of TBTA and TPhTA on the erythrocyte and its model membrane was investigated by the microscopic and spectroscopic methods. Interaction of tin complexes with the membrane was determined on the basis of hemolytic activity, changes i...
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The aim of the study was to investigate and compare the interaction of tributyltin (TBTA) and triphenyltin (TPhTA) 2-[4 (dimethylamino)phenylazo]benzoates complexes with the lipid membrane and plasmid DNA. Both TBTA and TPhTA belong to the group of promising anticancer agents. Differential scanning calorimetry method was employed to examine the heat signal associated with phase transitions of liposomes formed from dipalmitoylphosphatidylcholine (DPPC) or DPPC/cholesterol and modified with TBTA a...
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