Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP
Abstract
BACKGROUND AND PURPOSE An ATP‐binding cassette (ABC) transporter, breast cancer resistance protein (BCRP)/ ABCG2 , limits oral bioavailability of sulphasalazine. Here we examined the effect of curcumin, the principal curcuminoid of turmeric, on oral bioavailability of microdoses and therapeutic doses of sulphasalazine in humans. EXPERIMENTAL APPROACH Effects of curcumin were measured on the ATP‐dependent sulphasalazine uptake by hBCRP‐expressing...
Paper Details
Title
Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP
Published Date
Jun 27, 2012
Volume
166
Issue
6
Pages
1793 - 1803
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