Cytotoxic activity against a series of human tumour cell lines of some diorganotin(iv) 1,2-ethylenediamine N,N'-diacetates, N-(2-hydroxyethyl)- and N-(carbamoylmethyl)-iminodiacetates, and ortho-aminobenzoates.

Published on Jan 1, 1992in Anticancer Research 1.86
Marcel Gielen32
Estimated H-index: 32
,
Rudolph Willem37
Estimated H-index: 37
Abstract
The di-n-butyltin(IV) derivatives of N-(2-hydroxyethyl)- and N-(carbamoylmethyl)- iminodiacetic acid, compounds 1 and 2, the di-n-butyltin-, di-n-octyltin and dimethyltin-(IV) derivatives of 1,2-ethylene diamine N,N'-diacetic acid, compounds 3, 4 and 5, and di-n-butyltin bis-o-aminobenzoate, compound 6, were tested in vitro at the National Cancer Institute, Bethesda, Maryland, USA, for cytotoxic activity against a series of human tumor cell lines. Compounds 1 and 2 score globally satisfactorily since four of the five relevant selectivity or sensitivity parameters [DGI50, DTGI or DLC50 greater than 50, DH and MGDH greater than 75)] are statistically significant; compounds 4 and 6 score satisfactorily for only three of these parameters and compound 3, for only two. Compound 5, the dimethyltin derivative, is inactive.
  • References (0)
  • Citations (16)
References0
Cited By16
Maria Letizia Falcioni10
Estimated H-index: 10
(University of Camerino),
Maura Pellei27
Estimated H-index: 27
(University of Camerino),
Rosita Gabbianelli19
Estimated H-index: 19
(University of Camerino)
Abstract The discovery of the antitumor activity of cisplatin led several research groups to investigate the possible therapeutic applications of other metal-based compounds. Organotin(IV) complexes have been developed from organotin compounds that were employed in industry and agriculture as stabilizers and pesticides, respectively. A careful choice of the ligand coordinated to an organotin(IV) fragment can modulate the activity of the organotin(IV) complex and minimize its drawbacks. With this...
27 Citations Source Cite
Published on Jan 1, 2013in The Scientific World Journal
Mohamed M. Shoukry20
Estimated H-index: 20
,
Safaa S. Hassan4
Estimated H-index: 4
The interaction of 3,3-bis(1-methylimidazol-2-yl)propionate (BIMP) with dimethyltin(IV) dichloride (DMT), dibutyltin(IV) dichloride (DBT), and diphenyltin(IV) dichloride (DPT) is investigated at 25°C and 0.1 M ionic strength in water for dimethyltin(IV), and in a 50% dioxane-water mixture for dibutyltin(IV) and diphenyltin(IV). The stepwise formation constants of the 1 : 1 and 1 : 2 complexes formed in solution are calculated from potentiometric measurements using the nonlinear least-square prog...
Source Cite
Published on Apr 1, 2005in Applied Organometallic Chemistry 3.58
Marcel Gielen32
Estimated H-index: 32
(Vrije Universiteit Brussel),
Monique Biesemans34
Estimated H-index: 34
(Vrije Universiteit Brussel),
Rudolph Willem37
Estimated H-index: 37
(Vrije Universiteit Brussel)
An overview is given of the research performed by the authors at the Universite Libre de Bruxelles and Vrije Universiteit Brussel, including the kinetics, stereochemistry and mechanism of SE2 reactions at a saturated carbon atom, the synthesis of chiral organotin compounds and their configurational and optical stability, the fluxionality of trigonal bipyramidal metal atoms and the stereochemistry of SN2 reactions at tetrahedrally substituted P, Si, Ge, Sn atoms, the cytotoxicity of many series o...
156 Citations Source Cite
Published on Apr 1, 2006in Journal of Organometallic Chemistry 1.95
Claudia Pellerito14
Estimated H-index: 14
(University of Palermo),
László Nagy24
Estimated H-index: 24
(University of Szeged)
+ 1 AuthorsAttila Szorcsik11
Estimated H-index: 11
(University of Szeged)
This review summarized the literature and own data on the parent organotin(IV) compounds and complexes formed with biologically active ligands.
128 Citations Source Cite
Girish Barot11
Estimated H-index: 11
(Florida Atlantic University),
Kimberly Shahi10
Estimated H-index: 10
(University of Texas at Arlington)
+ 1 AuthorsCharles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University)
A series of organotin poly(ethylene glycols) were synthesized including the first water soluble organotin polymers. These products are all polymeric with weight average molecular weights about 105. Infrared spectroscopy shows the presence of moieties from both reactants and the formation of the Sn–O linkage. F MALDI MS shows the presence of up to over a hundred units and by isotopic abundance the presence of one, two, and three tin-containing ion fragments. The polymers inhibit the growth of can...
34 Citations Source Cite
Published on Jul 1, 2006in Applied Organometallic Chemistry 3.58
Muslim Khan4
Estimated H-index: 4
(Gomal University),
Musa Kaleem Baloch13
Estimated H-index: 13
(Gomal University)
+ 1 AuthorsObaidullah1
Estimated H-index: 1
(Gomal University)
Synthesis, spectral properties and in vitro cytotoxic behaviour of five new diorganotin(IV) complexes having general composition R′2SnR2 [R′ = 2-maleimidopropanoic acid and R = Me(1), Et(2), n-Bu(3), Ph(4), Bz(5)] have been investigated. Various spectroscopic methods like solid-state FT IR, 119mSn Mossbauer and solution-state multinuclear NMR (1H, 13C and 119Sn) have been employed for structural elucidation. In the solid state, [R2Sn(IV)]2+ moieties interacted with carboxylate group of the ligan...
11 Citations Source Cite
Published on May 27, 2011in Materials 2.47
Michael R. Roner19
Estimated H-index: 19
,
Charles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University)
+ 1 AuthorsGirish Barot11
Estimated H-index: 11
(Boston University)
Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very ...
17 Citations Source Cite
Published on Jul 1, 2006in Bulletin of the Chemical Society of Japan 3.53
Muslim Khan4
Estimated H-index: 4
,
Musa Kaleem Baloch13
Estimated H-index: 13
+ 1 AuthorsAbdul Malik24
Estimated H-index: 24
Five new diorganotin(IV) complexes of the general composition [R' 2 SnR 2 ] (where R': Me, Et, Bu, Ph, Bn and R: N-maleoyltranexamic acid) have been prepared and structurally characterized by means of FT IR and 119m Sn Mossbauer spectroscopy in the solid state. The solution-state structures were determined by means of multinuclear NMR ( 1 H, 13 C, and 119 Sn) spectroscopies. The spectroscopic data explained the 1:2 metal to ligand stoichiometry and hypervalency of Sn IV in a trans-octahedral arr...
3 Citations Source Cite
Published on Jan 1, 2008in ChemInform
Lorenzo Pellerito7
Estimated H-index: 7
,
Tiziana Fiore14
Estimated H-index: 14
+ 4 AuthorsEniko Nagy4
Estimated H-index: 4
(Hungarian Academy of Sciences)
4 Citations Source Cite
Girish Barot11
Estimated H-index: 11
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 3 AuthorsCharles E. Carraher23
Estimated H-index: 23
(Florida Atlantic University)
A variety of dibutyltin polyethers have been synthesized employing the interfacial polymerization technique. The products are polymers with degrees of polymerization ranging from 60 to 390. Infrared spectral and mass spectral results are consistent with the proposed structure. The products show good inhibition of a variety of cancer cells including those associated with bone, breast, prostrate, and lung cancers. Some also show good viral inhibition of the HSV-1 (herpes simplex) and Vaccina (smal...
26 Citations Source Cite