GABABreceptor-mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram-treated rats

Volume: 593, Issue: 1, Pages: 161 - 180
Published: Nov 25, 2014
Abstract
Key points Noradrenaline (NA)-releasing neurons in the locus coeruleus (LC) provide NA to the forebrain and play important roles in regulating many brain functions. LC neurons are subject to tonic inhibition mediated by GABAB receptors (GABABRs) and that the extent of the effect varies with ambient GABA levels. GABABR-mediated tonic inhibition can effectively tune the spontaneous firing rate (SFR) of LC neurons; it is developmentally regulated...
Paper Details
Title
GABABreceptor-mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram-treated rats
Published Date
Nov 25, 2014
Volume
593
Issue
1
Pages
161 - 180
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