Purity of antidotal oxime HI-6 DMS as an active pharmaceutical ingredient for auto-injectors and infusions
Abstract
As reactivators of inhibited acetylcholinesterase, oximes are essential antidotes in poisoning by organophosphorus compounds. Due to its superior efficacy in cases of soman, cyclosarin, and sarin poisoning, the oxime HI-6 represents a promising option for an active pharmaceutical ingredient (API) in the further development of antidote therapy for nerve agent poisoning. Developmental lots of HI-6 DMS (dimethanesulfonate) provided by different...
Paper Details
Title
Purity of antidotal oxime HI-6 DMS as an active pharmaceutical ingredient for auto-injectors and infusions
Published Date
Feb 24, 2012
Journal
Volume
4
Issue
3-4
Pages
199 - 207
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Notes
History