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Multi-Component Molecular-Level Body Composition Reference Methods: Evolving Concepts and Future Directions

Published on Apr 1, 2015in Obesity Reviews8.19
· DOI :10.1111/obr.12261
Steven B. Heymsfield101
Estimated H-index: 101
(Pennington Biomedical Research Center),
Cara B. Ebbeling35
Estimated H-index: 35
(Boston Children's Hospital)
+ 4 AuthorsDavid S. Ludwig66
Estimated H-index: 66
(Boston Children's Hospital)
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Abstract
Summary Excess adiposity is the main phenotypic feature that defines human obesity and that plays a pathophysiological role in most chronic diseases. Measuring the amount of fat mass present is thus a central aspect of studying obesity at the individual and population levels. Nevertheless, a consensus is lacking among investigators on a single accepted ‘reference’ approach for quantifying fat mass in vivo. While the research community generally relies on the multi-component body volume class of ‘reference’ models for quantifying fat mass, no definable guide discerns among different applied equations for partitioning the four (fat, water, protein and mineral mass) or more quantified components, standardizes ‘adjustment’ or measurement system approaches for model-required labelled water dilution volumes and bone mineral mass estimates, or firmly establishes the body temperature at which model physical properties are assumed. The resulting differing reference strategies for quantifying body composition in vivo leads to small, but under some circumstances, important differences in the amount of measured body fat. Recent technological advances highlight opportunities to expand model applications to new subject groups and measured components such as total body protein. The current report reviews the historical evolution of multi-component body volume-based methods in the context of prevailing uncertainties and future potential.
  • References (73)
  • Citations (27)
Cite
References73
Newest
Published on May 1, 2014in American Journal of Human Biology1.44
Ellen W. Demerath40
Estimated H-index: 40
(UMN: University of Minnesota),
David A. Fields28
Estimated H-index: 28
(University of Oklahoma Health Sciences Center)
Body composition assessment provides a sharper picture of the human biological response to genetic and environmental influences than measures of body size and weight. Infant body composition is particularly important as a marker of fetal adaptation and developmental programming of subsequent health and disease, but until recently, the range of options for measuring infant body composition was relatively narrow. The purpose of this Toolkit: Methods in Human Biology review is to provide a comprehe...
Published on Jul 1, 2013in Journal of Clinical Densitometry2.18
Joseph Wilson5
Estimated H-index: 5
(University of California, Berkeley),
Bo Fan29
Estimated H-index: 29
(UCSF: University of California, San Francisco),
John A. Shepherd47
Estimated H-index: 47
(University of California, Berkeley)
Abstract Total body volume is an important health metric used to measure body density, shape, and multicompartmental body composition but is currently only available through underwater weighing or air displacement plethysmography (ADP). The objective of this investigation was to derive an accurate body volume from dual-energy X-ray absorptiometry (DXA)–reported measures for advanced body composition models. Volunteers received a whole body DXA scan and an ADP measure at baseline (N=25) and 6mo (...
Published on Mar 1, 2013in The American Journal of Clinical Nutrition6.57
Joseph Wilson5
Estimated H-index: 5
(UC: University of California),
Boyd Josef Gimnicher Strauss38
Estimated H-index: 38
+ 2 AuthorsJohn A. Shepherd47
Estimated H-index: 47
(UC: University of California)
Background: Muscle wasting is a consequence of many primary conditions including sarcopenia, cachexia, osteoporosis, HIV/AIDS, and chronic kidney disease. Unfortunately, there is not a clinically accessible method to measure total body protein, which is the functional mass of muscle. Objective: We sought to derive a simple method to measure total body protein by using dual-energy X-ray absorptiometry (DXA) and bioimpedance analysis (BIA). Design: We retrospectively analyzed a clinical convenienc...
Published on Jan 1, 2013
Joseph Patrick Wilson1
Estimated H-index: 1
Author(s): Wilson, Joseph Patrick | Advisor(s): Shepherd, John A | Abstract: Diabetes and metabolic syndrome are global health problems associated with reduced life span, increased morbidity, and significant financial burdens on individuals and healthcare systems. Each of these disorders has unique body composition and body shape characteristics as it progresses forward. While the biology behind these disorders has made tremendous progress in the last fifty years, the most commonly used methods ...
Published on May 1, 2012in American Journal of Physical Anthropology2.66
Nathan Daniell8
Estimated H-index: 8
(UniSA: University of South Australia),
Tim Olds48
Estimated H-index: 48
(UniSA: University of South Australia),
Grant R. Tomkinson20
Estimated H-index: 20
(UniSA: University of South Australia)
Measurements of whole body surface area (WBSA) have important applications in numerous fields including biological anthropology, clinical medicine, biomechanics, and sports science. Currently, WBSA is most often estimated using predictive equations due to the complex and time consuming methods required for direct measurement. The main aim of this study was to identify whether there were significant and meaningful differences between WBSA measurements taken using a whole body three-dimensional (3...
Published on Mar 1, 2012in The American Journal of Clinical Nutrition6.57
Moonseong Heo38
Estimated H-index: 38
,
Myles S. Faith15
Estimated H-index: 15
(UNC: University of North Carolina at Chapel Hill)
+ 1 AuthorsSteven B. Heymsfield62
Estimated H-index: 62
(Pennington Biomedical Research Center)
Background: To date, there is no consensus regarding adult cutoffs of percentage of body fat or estimated cutoffs on the basis of nationally representative samples with rigorous body-composition measurements. Objective: We developed cutoffs of percentage of body fat on the basis of the relation between dual-energy x-ray absorptiometry– measured fat mass and BMI (in kg/m 2 ) stratified by sex, age, and race-ethnicity by using 1999–2004 NHANES data. Design: A simple regression (percentage of body ...
Published on Mar 1, 2012in The American Journal of Clinical Nutrition6.57
Russell J. de Souza35
Estimated H-index: 35
,
George A. Bray114
Estimated H-index: 114
+ 6 AuthorsSteven R. Smith71
Estimated H-index: 71
Background: Weight loss reduces body fat and lean mass, but whether these changes are influenced by macronutrient composition of the diet is unclear. Objective: We determined whether energy-reduced diets that emphasize fat, protein, or carbohydrate differentially reduce total, visceral, or hepatic fat or preserve lean mass. Design: In a subset of participants in a randomized trial of 4 weightloss diets, body fat and lean mass (n = 424; by using dual-energy X-ray absorptiometry) and abdominal and...
Published on Jan 1, 2012in The American Journal of Clinical Nutrition6.57
Joseph Wilson5
Estimated H-index: 5
,
Kathleen Mulligan48
Estimated H-index: 48
+ 7 AuthorsJohn A. Shepherd47
Estimated H-index: 47
Background: Total body volume (TBV), with the exclusion of internal air voids, is necessary to quantify body composition in Lohman's 4-compartment (4C) model. Objective: This investigation sought to derive a novel, TBV measure with the use of only dual-energy X-ray absorptiometry (DXA) attenuation values for use in Lohman's 4C body composition model. Design: Pixel-specific masses and volumes were calculated from low- and high-energy attenuation values with the use of first principle conversions ...
Published on Jan 1, 2012in International Journal of Obesity4.51
Jonathan C. K. Wells60
Estimated H-index: 60
(ICH: UCL Institute of Child Health),
Philip C. Treleaven16
Estimated H-index: 16
,
Supiya Charoensiriwath3
Estimated H-index: 3
Body shape by 3-D photonic scanning in Thai and UK adults: comparison of national sizing surveys
Published on Nov 1, 2011in Journal of Biological Dynamics1.64
Diana M. Thomas26
Estimated H-index: 26
(MSU: Montclair State University),
Corby K. Martin45
Estimated H-index: 45
(Pennington Biomedical Research Center)
+ 3 AuthorsJames A. Levine60
Estimated H-index: 60
(Mayo Clinic)
Excessive weight in adults is a national concern with over 2/3 of the US population deemed overweight. Because being overweight has been correlated to numerous diseases such as heart disease and type 2 diabetes, there is a need to understand mechanisms and predict outcomes of weight change and weight maintenance. A simple mathematical model that accurately predicts individual weight change offers opportunities to understand how individuals lose and gain weight and can be used to foster patient a...
Cited By27
Newest
Published on Apr 17, 2019in Nutrients4.17
Abbie E. Smith-Ryan13
Estimated H-index: 13
,
Katie R. Hirsch5
Estimated H-index: 5
+ 2 AuthorsEric T. Trexler9
Estimated H-index: 9
The purpose of this paper was to determine the effect of replacing breakfast with a high-fat drink on fat mass (FM), lean mass (LM), percent body fat (%BF), visceral fat (VAT), resting metabolic rate (RMR), fuel utilization (RER), blood lipids and satiety in overweight and obese adults. Healthy adults (n = 42; 21 Females; body mass index (BMI): 32.8 ± 4.6 kg·m−2) were randomized to control (CON; n = 21) or meal replacement (MRP; n = 22) groups. Body composition was measured using a four-compartm...
Published on Mar 1, 2019in Journal of Clinical Densitometry2.18
Li-Wen Lee1
Estimated H-index: 1
(CGUST: Chang Gung University of Science and Technology),
Yu-San Liao1
Estimated H-index: 1
(CGUST: Chang Gung University of Science and Technology)
+ 2 AuthorsChing-Chi Chi1
Estimated H-index: 1
(CGU: Chang Gung University)
Abstract Background: Bioelectrical impedance analysis (BIA) is a widely available tool which provides mineral estimate. However, BIA is not currently recognized as a bone mineral measuring method. This study aimed to explore the ability of BIA to predict bone mineral content (BMC) in children, using dual-energy X-ray absorptiometry as a gold standard. Methods: Healthy children aged 6–12years (n = 176) were recruited for BIA and dual-energy X-ray absorptiometry measurements. Predictive models wer...
Published on Feb 1, 2019in Clinical Nutrition6.40
Elisabetta Marini16
Estimated H-index: 16
(University of Cagliari),
Francesco Campa2
Estimated H-index: 2
(UNIBO: University of Bologna)
+ 5 AuthorsAnaliza M. Silva28
Estimated H-index: 28
(University of Lisbon)
To analyze the association of classic and specific bioelectrical impedance vector analysis (BIVA) and phase angle with reference techniques for the assessment of body composition in athletes.202 athletes of both sexes (men: 21.5 ± 5.0; women: 20.7 ± 5.1) engaged in different sports were evaluated during the in-season period. Bioelectrical resistance (R, ohm) and reactance (Xc, ohm) were obtained with a phase-sensitive 50 kHz bioelectrical impedance analysis device. The classic and specific BIVA ...
Published on Jan 1, 2019in Advances in Nutrition7.24
Joel Conkle5
Estimated H-index: 5
(Emory University),
Reynaldo Martorell72
Estimated H-index: 72
(Emory University),
Reynaldo Martorell (Emory University)
Published on Oct 1, 2018in The American Journal of Clinical Nutrition6.57
Bennett K. Ng5
Estimated H-index: 5
(UCSF: University of California, San Francisco),
Yong E Liu1
Estimated H-index: 1
(UH: University of Hawaii)
+ 5 AuthorsJohn A. Shepherd47
Estimated H-index: 47
(UH: University of Hawaii)
Published on Mar 1, 2018in Clinical Physiology and Functional Imaging2.27
Abbie E. Smith-Ryan13
Estimated H-index: 13
(UNC: University of North Carolina at Chapel Hill),
Malia N.M. Blue4
Estimated H-index: 4
(UNC: University of North Carolina at Chapel Hill)
+ 1 AuthorsKatie R. Hirsch5
Estimated H-index: 5
(UNC: University of North Carolina at Chapel Hill)
Published on Feb 1, 2018in Contemporary Clinical Trials2.28
Cara B. Ebbeling35
Estimated H-index: 35
(Boston Children's Hospital),
Gloria Klein2
Estimated H-index: 2
(Boston Children's Hospital)
+ 13 AuthorsBridget M. Hron2
Estimated H-index: 2
(Boston Children's Hospital)
Abstract Background While many people with overweight or obesity can lose weight temporarily, most have difficulty maintaining weight loss over the long term. Studies of dietary composition typically focus on weight loss, rather than weight-loss maintenance, and rely on nutrition education and dietary counseling, rather than controlled feeding protocols. Variation in initial weight loss and insufficient differentiation among treatments confound interpretation of results and compromise conclusion...
Published on Jan 26, 2018
Carla M. Prado29
Estimated H-index: 29
(U of A: University of Alberta),
Sarah A. Elliott3
Estimated H-index: 3
(U of A: University of Alberta),
João Felipe Mota11
Estimated H-index: 11