Amyloid β: one of three danger‐associated molecules that are secondary inducers of the proinflammatory cytokines that mediateAlzheimer's disease

This review concerns how the primary inflammation preceding the generation of certain key damage‐associated molecular patterns ( DAMPs ) arises in A lzheimer's disease ( AD ). In doing so, it places soluble amyloid β (Aβ), a protein hitherto considered as a primary initiator of AD, in a novel perspective. We note here that increased soluble Aβ is one of the proinflammatory cytokine‐induced DAMPs recognized by at least one of the toll‐like...