Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
Abstract
The MDR1 gene, responsible for multidrug resistance in human cells, encodes a broad specificity efflux pump (P-glycoprotein). P-glycoprotein consists of two similar halves, each half including a hydrophobic transmembrane region and a nucleotide-binding domain. On the basis of sequence homology between the N-terminal and C-terminal halves of P-glycoprotein, we have previously suggested that this gene arose by duplication of a primordial gene. We...
Paper Details
Title
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
Published Date
Jan 1, 1990
Volume
265
Issue
1
Pages
506 - 514
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