Modeling and control of ibuprofen crystal growth and size distribution

In this work, we focus on multiscale modeling and control of a seeded batch crystallization process used to produce ibuprofen crystals. For the modeling of the crystal growth process, we consider kinetic Monte Carlo (kMC) simulations comprising of molecule adsorption, desorption, and migration type microscopic surface events. To account for growth rate variability, we propose a model for growth rate dispersion (GRD), based on the available...