Longevity through DNA damage tolerance

The genome in every cell is constantly attacked by a large variety of exogenous and endogenous genotoxins. DNA damage has long been known as causal factor for cancer development and has more recently also been recognized as driving force of the aging process.1 Recent insights have shed light on how organisms respond to DNA damage accumulation by employing bona fide longevity assurance pathways. A key longevity assurance pathway had been...