Transfer factor and other mediators of cellular immunity.

Published on Sep 1, 1970in American Journal of Pathology3.762
H S Lawerence23
Estimated H-index: 23
Fred T. Valentine35
Estimated H-index: 35
  • References (17)
  • Citations (35)
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#1H S Lawerence (NYU: New York University)H-Index: 23
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When sensitive lymphocytes are cultured with the appropriate antigen, lymphoblasts appear after 24–48 hr of incubation and the number of these increases steadily from the 2nd to the 6th or 7th day. Our problem was to discover, at a cellular level, how this increase takes place; whether it is a massive response of many cells, stepwise recruitment of cells into the lymphoblast class, or simply repeated division of a few cells to form clones. In these experiments lymphocytes were incubated with ant...
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Lymph node lymphocytes obtained from guinea pigs exhibiting delayed hypersensitivity are stimulated in vitro by specific antigen to produce a soluble factor that is chemotactic in vitro for mononuclear macrophages. The material is nondialyzable, relatively heat stable, and elutes from Sephadex G-100 in the fraction containing molecules smaller than immunoglobulins.
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Mutual in vitro cell destruction resulted when nonimmune or immune mouse or rat small lymphocytes were attached to genetically dissimilar target cells with phytohemagglutinin or xenogeneic antibody. The ability to induce this reaction resided only with viable cells of lymphoid origin. The step(s) leading to aggressor-target cell destruction observed in these studies is suggested by the following sequence: a) attachment of the aggressor cell to the target cell, b) membrane site(s) interaction bet...
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Immunological studies were conducted on a young girl with chronic muco-cutaneous moniliasis and staphylococcal botryomycosis. A cellular immune defect was demonstrated in three ways: (1) delayed hypersensitivity reactions could not be elicited with a standard panel of antigens used for assaying this phenomenon, (2) prolonged survivals of both parental and unrelated skin homografts were obtained, and (3) only one-third as many peripheral blood lymphocytes showed effects of stimulation by phytohae...
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#1Roy E. Brown (MUK: Makerere University)H-Index: 1
#2Michael Katz (MUK: Makerere University)H-Index: 4
Eight children with kwashiorkor, four children with marasmus, and five well-nourishedchildren used as controls, all of whom had been tuberculin negative, received passive transfer of material from lymphocytes of a tuberculin positive donor. All of them became tuberculin positive. The results suggest that there was no impairment of delayed hypersensitivity reaction in the malnourished children. It is possible, however, that they would be unable to initiate such a reaction in response to an origin...
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#1Peter BaramH-Index: 4
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Summary Two fractions from tuberculin hypersensitive human white blood cells have been found capable of transferring tuberculin delayed hypersensitivity. One of these (C′-5) is a polynucleotide containing adenine, guanine and cytosine, but no uracil. The second transfer factor is contained in a larger molecular weight (A′) fraction found to have γG-globulin and other globulin and probably α 1 lipoprotein as well as ribose indicating RNA. A fraction containing macroglobulin was unable to transfer...
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1. Abstract 1.1.Aim:More and more various mixtures of potentially bioactive molecules reach the market, however the serious testing is usually lacking. 1.2.Methods:In this study we directly compared the effects of eleven different combinations on the immune reactions. 1.3.Results:We evaluated phagocytic activity, IL-2 and superoxide anion formation, NK cell activity, antibody response and breast cancer inhibition. Our results demonstrated strong differences among individual combinations. 1.4.Con...
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Background: Lately, more and more preparation of various cocktails or mixtures of bioactive modulators have been introduced. Their true activity is, however, rarely tested. Aim: To compare six commercially available, glucan-based immunostimulators. Methods: Immunological effects of tested combinations were measured by evaluation of phagocytosis of synthetic particles by peripheral blood neutrophils, production of IL-2 by mouse splenocytes, production of superoxide anion and nitrite oxide, antibo...
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This brief review focuses on the way that our understanding of virus-specific CD8 + T-cell-mediated immunity evolved, giving particular attention to the early impact of the program at the Australian National University. The story developed through a sequence of distinct eras, each of which can be defined in the context of the technologies available at that time. The progress has been enormous, but there is a great deal still to be learned. A particular challenge is to use what we know for human ...
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Facteurs predisposants a l'energie chez le malade chirurgical: malnutrition, traumatisme, anergie et cancer
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Since, as indicated in Chapter 5, defective immunity, notably cell-mediated immunity, is closely associated with progressive coccidioidomycosis, attempts to treat the disease by altering the host response are eminently logical. In coccidioidomycosis, almost all the clinical experience with this approach has been by the use of transfer factor. Conversely, probably no disease has provided more rationale for further clinical study of transfer factor.
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Publisher Summary This chapter discusses the circulating nucleic acids in higher organisms. DNA is able to leave bacteria and enter other bacteria and the mechanisms and situations involved are readily understood. Bacterial DNA can move from members of one strain to those of another by means of conjugation or transduction, which does not strictly involve extracellular release of DNA. Bacteria possess several extra chromosomal factors including the F factor (the first fertility factor), R factors...
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Publisher Summary Immunologic manipulations to control tumor growth can essentially be divided into passive and active categories. Passive immunotherapy refers to approaches in which immunologic reagents, such as serum, cells, or cell products that are thought to have antitumor activity, are administered to a tumor-bearing host. This chapter reviews recent studies of the use of passive immunotherapy for the treatment of cancer in animals and man. Immune depression in cancer patients has been wel...
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Thirtecn patients with subacute sclerosing panencephalitis (S.S.P.E.) at different stages of the disease were admitted for transfer factor treatment. The transfer factor was prepared from non-selected blood bank donors. The activity of the transfer factor was tested in patients with diseases other than S.S.P.E. and was found to be either clinically or immunologically active.
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