Propofol restores TRPV 1 sensitivity via a TRPA 1‐, nitric oxide synthase‐dependent activation of PKC ε

We previously demonstrated that the intravenous anesthetic, propofol, restores the sensitivity of transient receptor potential vanilloid channel subtype‐1 ( TRPV 1) receptors via a protein kinase C epsilon ( PKC ε )‐dependent and transient receptor potential ankyrin channel subtype‐1 ( TRPA 1)‐dependent pathway in sensory neurons. The extent to which the two pathways are directly linked or operating in parallel has not been determined. Using a...