Match!

IgG4-Related Pachymeningitis: Evidence of Intrathecal IgG4 on Cerebrospinal Fluid Analysis

Published on Mar 6, 2012in Annals of Internal Medicine19.32
· DOI :10.7326/0003-4819-156-5-201203060-00025
Emanuel Della Torre3
Estimated H-index: 3
(UniSR: Vita-Salute San Raffaele University),
E. Bozzolo17
Estimated H-index: 17
(UniSR: Vita-Salute San Raffaele University)
+ 2 AuthorsMaria Grazia Sabbadini35
Estimated H-index: 35
(UniSR: Vita-Salute San Raffaele University)
Cite
  • References (7)
  • Citations (29)
Cite
References7
Newest
Published on Aug 1, 2011in No shinkei geka. Neurological surgery
Koichi Kato8
Estimated H-index: 8
,
Tamano Y1
Estimated H-index: 1
+ 4 AuthorsNomura K1
Estimated H-index: 1
Abstract Hypertrophic pachymeningitis is a rare disease, and the fibrosing inflammatory process causes a thickening of the dura mater. A 62-year-old male undergoing corticosteroid therapy for autoimmune pancreatitis presented with headache and right facial numbness. Brain CT and MRI revealed thickened mass lesion around the tentorium. The specimen obtained by biopsy showed a small number of immunostain areas positive for IgG and IgG4. Systemic IgG4 related disease entity is proposed and analyzed...
Published on Dec 1, 2010in Acta Neuropathologica18.17
Katherine M. Lindstrom1
Estimated H-index: 1
(UVA: University of Virginia),
John B. Cousar31
Estimated H-index: 31
(UVA: University of Virginia),
M. Beatriz S. Lopes28
Estimated H-index: 28
(UVA: University of Virginia)
IgG4-related disease has evolved from originally being recognized as a form of pancreatitis to encompass diseases of numerous organs including the hypophysis and one reported case of dural involvement. A search of the University of Virginia, Division of Neuropathology files for 10 years identified ten cases of unexplained lymphoplasmacytic meningeal inflammation that we then evaluated using immunohistochemical stains for IgG4 and IgG. Ten control cases including sarcoidosis (4), tuberculosis (1)...
Published on Oct 12, 2010in Neurology8.69
Arifumi Kosakai15
Estimated H-index: 15
,
Daisuke Ito31
Estimated H-index: 31
+ 3 AuthorsNaoki Suzuki46
Estimated H-index: 46
Immunoglobulin G (IgG)4-related disease is a recently defined disease entity that is characterized by elevated serum IgG4 levels and abundant infiltration of IgG4-positive plasma cells and high-grade sclerosis of the affected region.1 This disease includes autoimmune pancreatitis, Mikulicz disease, pseudotumor of the lung, tubulointerstitial nephritis, and Riedel thyroiditis,2 but the only CNS involvement that has been reported so far is hypophysitis.3 In this report, a case of intracranial IgG4...
Published on Sep 1, 2010in Advances in Anatomic Pathology3.53
Wah Cheuk30
Estimated H-index: 30
,
John K. C. Chan79
Estimated H-index: 79
An elevated serum titer of immunoglobulin G4 (IgG4), the least common (3% to 6%) of the 4 subclasses of IgG, is a surrogate marker for the recently characterized IgG4-related sclerosing disease. The syndrome affects predominantly middle-aged and elderly patients, with male predominance. The patients
Published on Jan 1, 2010in Journal of the Neurological Sciences2.65
Franziska Di Pauli12
Estimated H-index: 12
(Innsbruck Medical University),
Viktoria Gredler7
Estimated H-index: 7
(Innsbruck Medical University)
+ 7 AuthorsThomas Berger32
Estimated H-index: 32
(Innsbruck Medical University)
Abstract We have analyzed immunoglobulin (Ig) isotypes and IgG subclasses in cerebrospinal fluid (CSF) and serum of patients with multiple sclerosis (MS) and other neurological diseases to determine whether different Ig isotype patterns correlate with clinical or paraclinical findings and CSF B cell populations. Intrathecal IgG1 synthesis was elevated in MS patients. An increased intrathecal IgM production was found in patients with a higher cerebral MRI lesion burden, whereas other clinical and...
Published on Aug 1, 2009in The American Journal of Surgical Pathology6.16
Siu-Ki Chan1
Estimated H-index: 1
,
Wah Cheuk30
Estimated H-index: 30
+ 1 AuthorsJohn K. C. Chan79
Estimated H-index: 79
Abstract IgG4-related sclerosing disease is a distinctive mass-forming lesion with frequent systemic involvement, most frequently the pancreas, salivary glands, and lacrimal glands. This report describes a case manifesting with a previously unrecognized form of central nervous system involvement. The 37-year-old man presented with signs and symptoms of spinal cord compression at the thoracic level 9. Magnetic resonance imaging revealed an elongated dural mass extending from the fifth to tenth th...
Published on Dec 1, 2001in Journal of Neuroimmunology2.83
Bernhard Greve12
Estimated H-index: 12
(University of Tübingen),
C.G.M Magnusson1
Estimated H-index: 1
(KI: Karolinska Institutet)
+ 1 AuthorsRobert Weissert38
Estimated H-index: 38
(University of Tübingen)
Abstract IgG, its subclasses and IgE concentrations were measured in cerebrospinal fluid (CSF) and serum of multiple sclerosis (MS) patients and matched controls as surrogate markers for type 1 and type 2 immunity. IgE indices were significantly reduced in MS patients compared to controls. In contrast, IgG1 was elevated in CSF of MS patients and elevated indices indicated intrathecal synthesis. Because isotype switching to IgE and IgG4 is driven by type 2 immunity and occurrence of IgG1 has prev...
Cited By29
Newest
Published on Jun 1, 2019in World Neurosurgery1.72
Stephen J. Slade (Virginia Mason Medical Center), Erin M. Bauer (Virginia Mason Medical Center)+ 1 AuthorsAmish J. Dave (Virginia Mason Medical Center)
Abstract Background Back pain is a leading reason patients seek medical attention. While musculoskeletal causes are common, rarer etiologies can present. Case Description A 50-year-old male presented with 2 months of isolated upper back pain initially suspected to be secondary to overuse muscular strain. Over the next 3 months, his pain worsened, and he developed lower extremity dysesthesias and subjective weakness despite a normal neurological exam. Non-revealing laboratory workup included norm...
Published on May 1, 2019in Seminars in Arthritis and Rheumatism5.07
Cléa Melenotte5
Estimated H-index: 5
,
Julie Seguier1
Estimated H-index: 1
+ 20 AuthorsLaurent Daniel30
Estimated H-index: 30
Abstract Pachymeningitis is rare, either idiopathic or secondary to inflammatory disorders, after tumoral, surgical or infectious causes have been excluded. The fibroinflammatory IgG4-related disease is one of the etiologies of pachymeningitis with only few cases reported yet. From a single referral regional center, we evaluated the frequency of IgG4-related disease as the cause of inflammatory pachymeningitis in 10% of cases. From a National case registry of IgG4-related disease the pachymening...
Published on Feb 12, 2018in Frontiers in Immunology4.72
Inga Koneczny3
Estimated H-index: 3
(Medical University of Vienna)
IgG4 autoimmune diseases are characterized by the presence of antigen-specific autoantibodies of the IgG4 subclass, and contain well-characterised diseases such as MuSK myasthenia gravis, pemphigus and thrombotic thrombocytopenic purpura. In recent years several new diseases were identified, and by now fourteen antigens targeted by IgG4 autoantibodies have been described. The IgG4 subclass is considered immunologically inert and functionally monovalent due to structural differences compared to o...
Published on Nov 1, 2017in Clinical Imaging1.14
Mary Maher1
Estimated H-index: 1
(CUMC: Columbia University Medical Center),
George Zanazzi19
Estimated H-index: 19
(CUMC: Columbia University Medical Center)
+ 2 AuthorsTony T. Wong3
Estimated H-index: 3
(CUMC: Columbia University Medical Center)
Abstract IgG4-related disease is an immune-mediated fibro-inflammatory condition that affects multiple organ systems. When the pachymeninges are involved, it is termed IgG4-related hypertrophic pachymeningitis (IgG4-RHP). We present a 79-year-old woman with back pain found to have IgG4-RHP localized exclusively in the spine who was also seropositive for myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA). This case is the first known report of IgG4-RHP in the spine with MPO-ANCA an...
Published on Nov 1, 2017in International Journal of Rheumatic Diseases1.94
Andreu Fernández Codina7
Estimated H-index: 7
(Autonomous University of Barcelona),
Manuel Hernández-González3
Estimated H-index: 3
(Autonomous University of Barcelona)
+ 3 AuthorsFernando Martínez-Valle7
Estimated H-index: 7
(Autonomous University of Barcelona)
Ke Zheng1
Estimated H-index: 1
(Peking Union Medical College Hospital),
Fei Teng1
Estimated H-index: 1
(Peking Union Medical College Hospital),
Xue-Mei Li1
Estimated H-index: 1
(Peking Union Medical College Hospital)
Abstract Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized clinical entity that often involves multiple organs; it is characterized by high levels of serum immunoglobulin G4 (IgG4), dense infiltration of IgG4+ cells, and storiform fibrosis. Cellular immunity, particularly T cell-mediated immunity, has been implicated in the pathogenesis of IgG4-RD. The most frequent renal manifestations of IgG4-RD are IgG4-related tubulointerstitial nephritis, membranous glomerulonephropathy (...
Published on Jun 1, 2017in Revue de Médecine Interne0.81
Introduction La maladie associee aux IgG4 (MAG-4) est une maladie rare regroupant des manifestations cliniques tres variees, ayant comme caracteristique commune une reaction inflammatoire et immunitaire avec evolution fibrosante. Les differentes manifestations cliniques sont plus ou moins frequentes dans cette maladie, et la pachymeningite reste un mode de presentation peu commun. Nous rapportons ici l’observation d’un homme de 81 ans dont les violentes cephalees ont fait decouvrir une pachymeni...
Published on May 1, 2017in Current Opinion in Rheumatology3.85
Bozzalla Cassione E1
Estimated H-index: 1
,
John H. Stone67
Estimated H-index: 67
Purpose of review Remarkable insights have been gleaned recently with regard to the pathophysiology of IgG4-related disease (IgG4-RD). These findings have direct implications for the development of targeted strategies for the treatment of this condition. Recent findings Oligoclonal expansions of cells of both the B and T lymphocyte lineages are present in the blood of patients with IgG4-RD. Oligoclonal expansions of plasmablasts are a good biomarker for disease activity. An oligoclonally expande...
Published on Apr 1, 2017in Current Treatment Options in Neurology3.57
Bernardo Baptista1
Estimated H-index: 1
,
Alina Casian6
Estimated H-index: 6
(Guy's and St Thomas' NHS Foundation Trust)
+ 2 AuthorsClaire M Rice2
Estimated H-index: 2
(Southmead Hospital)
IgG4-related disease (IgG4-RD) is a multisystem inflammatory disorder. Early recognition of IgG4-RD is important to avoid permanent organ dysfunction and disability. Neurological involvement by IgG4-RD is relatively uncommon, but well recognised—hypertrophic pachymeningitis and hypophysitis are the most frequent manifestations. Although the nervous system may be involved in isolation, this more frequently occurs in conjunction with involvement of other systems. Elevated circulating levels of IgG...