Activity of Some Plant Extracts Against Multi-Drug Resistant Human Pathogens
Published on Jan 1, 2009in Iranian Journal of Pharmaceutical Research1.18
· DOI :10.22037/ijpr.2010.825
Plants used for traditional medicine contain a wide range of substances which can be used to treat various infectious diseases. Hence, antibacterial activities of ethanolic extracts of 19 plant species were studied against multi-drug resistant clinical isolates using agar well diffusion method. Extracts of Liquidambar orientalis , Vitis vinifera , Rosmarinus officinalis , Punica granatum , Cornus sanguinea , Euphorbia peplus , Ecballium elaterium , Inula viscosa and Liquidambar orientalis showed broad-spectrum antibacterial activity with inhibition zones ranging from 8 to 26 mm. The most resistant organisms were Escherichia coli ( E. coli ) (Ampicillin-, amoxycillin- and sulfamethoxazole-resistant), Stenotrophomonas maltophilia ( S. maltophilia ) (Amoxycillin- and nalidixic acid-resistant) and Klebsiella pneumoniae ( K. pneumoniae ) (Ampicillin-, amoxycillin- and aztreonam-resistant), and the most susceptible species were Staphylococcus aureus ( S. aureus ) (Penicillin G- and oxacillin-resistant), Streptococcus pyogenes ( S. pyogenes ) (Penicillin G-, erythromycin- and clindamycin-resistant) and Pseudomonas aeruginosa ( P. aeruginosa ) (Sulfamethoxazole- and novobiocin-resistant), respectively. Minimum Inhibitory Concentrations (MIC) of crude extracts were determined for the seven highly active plants showing activity against methicillin resistant S. aureus (MRSA), E. coli , P. aeruginosa , S. pneumoniae and the reference bacteria ( E. coli ATCC 11229 and Kocuria rhizophila ATCC 9341 NA). MICs of active extracts ranged from 8 to 14.2 mg/mL against one or other test bacteria.