Constitutive HER2 signaling promotes breast cancer metastasis through cellular senescence

Senescence, a terminal cell proliferation arrest, can be triggered by oncogenes. Oncogene‐induced senescence is considered a tumor defense barrier. However, several findings show that, under certain circumstances, senescent cells may favor tumor progression because of their secretory phenotype. In this communication we will show that the expression in different breast epithelial cell lines of p95HER2, a constitutively active fragment of the...