New regulation mechanisms of osteoclast differentiation

Osteoclasts play a crucial role in both physiological and pathological bone resorption. It is, thus, of compelling importance to understand the molecular mechanisms of osteoclast regulation. Because receptor activator of nuclear factor-κB ligand (RANKL) is the key cytokine that induces osteoclast differentiation, we have focused on the investigation of RANKL signaling and RANKL-expressing cells. Here, we summarize the recent advances in the...