Original paper

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

Nature50.50
Volume: 414, Issue: 6861, Pages: 308 - 313
Published: Nov 1, 2001
Abstract
In addition to coordinating immune and inflammatory responses, NF-kappaB/Rel transcription factors control cell survival. Normally, NF-kappaB dimers are sequestered in the cytoplasm by binding to inhibitory IkappaB proteins, and can be activated rapidly by signals that induce the sequential phosphorylation and proteolysis of IkappaBs. Activation of NF-kappaB antagonizes apoptosis or programmed cell death by numerous triggers, including the...
Paper Details
Title
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
Published Date
Nov 1, 2001
Journal
Volume
414
Issue
6861
Pages
308 - 313
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