Post-translational Modifications of α5β1 Integrin by Glycosaminoglycan Chains

Cell-fibronectin interactions, mediated through several different receptors, have been implicated in a wide variety of cellular properties. Among the cell surface receptors for fibronectin, integrins are the best characterized, particularly the prototype α5β1 integrin. Using [125I]iodine cell surface labeling or metabolic radiolabeling with sodium [35S]sulfate, we identified α5β1 integrin as the only sulfated integrin among β1 integrin...